We use bacteriophages for their inherent property, as bacterial killers. We develop design/formulation criteria for bacteriophage therapeutics against common infections on the skin, medical implants, gastrointestinal tract, and respiratory system, specifically those that are in biofilm mode and antibiotic resistant.
In their simplest form, bacteriophages are bionanoparticles than can propagate themselves and self-assemble. These properties make bacteriophages more powerful than synthetic nanoparticles. We also pack bacteriophages into solid form to design antimicrobial biomaterials, gels and coatings.
Bacteriophages are very effective at finding and specifically targeting their host bacteria in nature. Because bacteriophages are so good at targeting their prey (bacteria) in nature, we use them to design novel methods of detecting and diagnosing infectious diseases.
We investigate aerosolized phage to understand the behaviour of infectious aerosols, as well as to design inhalable therapeutics. We research the performance of respirators to aerosolized viruses and bacteria under clinically relevant conditions.